The introduction (the first seven minutes) to this Sam Harris podcast on death is extremely profound. It had a pretty significant impact on how Anne and I have been thinking about our choices and our near future, having to make decisions about our careers and money vs the rest of our lives and our time together.
Personally, I didn't find the interview itself very compelling. Given that we're so far behind on podcasts, we stopped listening 2/3rds through. But I strongly advise taking just seven minutes to listen to Sam's introduction. I have tears in my eyes just listening to it again.